RPP38

RPP38
Identifiers
Aliases	RPP38, ribonuclease P/MRP subunit p38
External IDs	OMIM: 606116; MGI: 2443607; HomoloGene: 4680; GeneCards: RPP38; OMA:RPP38 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	15,139,818 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	3,333,680 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; right uterine tube; ; mucosa of transverse colon; ; sperm; ; nasal epithelium; ; oocyte; ; granulocyte;
	Top expressed in
	primary oocyte; ; spermatocyte; ; secondary oocyte; ; genital tubercle; ; zygote; ; morula; ; epiblast; ; spermatid; ; tail of embryo; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; protein binding; ribonuclease P activity;
Cellular component	nucleus; nucleolus; nucleoplasm; nucleolar ribonuclease P complex; fibrillar center;
Biological process	RNA phosphodiester bond hydrolysis, endonucleolytic; RNA phosphodiester bond hydrolysis; tRNA processing; tRNA 5'-leader removal;
	Sources:Amigo / QuickGO
Orthologs
	10557
	227522
	ENSG00000152464
	ENSMUSG00000049950
	P78345; Q5VUC3
	A2AJG0
	NM_001097590; NM_001265601; NM_006414; NM_183005
	NM_001013376
	NP_001091059; NP_001252530; NP_006405; NP_892117
	NP_001013394
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.^[5]^[6]^[7]

Interactions

RPP38 has been shown to interact with POP4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049950 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eder PS, Kekuda R, Stolc V, Altman S (March 1997). "Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1101–6. Bibcode:1997PNAS...94.1101E. doi:10.1073/pnas.94.4.1101. PMC 19751. PMID 9037013.
^ Jarrous N, Eder PS, Guerrier-Takada C, Hoog C, Altman S (June 1998). "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P". RNA. 4 (4): 407–17. PMC 1369627. PMID 9630247.
^ "Entrez Gene: RPP38 ribonuclease P/MRP 38kDa subunit".
^ Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jarrous N, Wolenski JS, Wesolowski D, Lee C, Altman S (1999). "Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P". J. Cell Biol. 146 (3): 559–72. doi:10.1083/jcb.146.3.559. PMC 2150555. PMID 10444065.
Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–41. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.
Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152464 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049950 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9037013-5] Eder PS, Kekuda R, Stolc V, Altman S (March 1997). "Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1101–6. Bibcode:1997PNAS...94.1101E. doi:10.1073/pnas.94.4.1101. PMC 19751. PMID 9037013.

[pmid9630247-6] Jarrous N, Eder PS, Guerrier-Takada C, Hoog C, Altman S (June 1998). "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P". RNA. 4 (4): 407–17. PMC 1369627. PMID 9630247.

[entrez-7] "Entrez Gene: RPP38 ribonuclease P/MRP 38kDa subunit".

[pmid15096576-8] Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

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Interactions

References

Further reading