RuvB-like 1

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Protein RUVBL1 PDB 2c9o.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ECP-54, NMP 238, RuvB like AAA ATPase 1
External IDs MGI: 1928760 HomoloGene: 37839 GeneCards: RUVBL1
RNA expression pattern
PBB GE RUVBL1 201614 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 128.06 – 128.15 Mb Chr 6: 88.47 – 88.5 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene.[3] RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein.[4] Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.


RuvB-like 1 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: RUVBL1 RuvB-like 1 (E. coli)". 
  4. ^ Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (February 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". J. Mol. Biol. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868. 
  5. ^ a b Park J, Wood MA, Cole MD (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. 22 (5): 1307–16. doi:10.1128/mcb.22.5.1307-1316.2002. PMC 134713Freely accessible. PMID 11839798. 
  6. ^ Bauer A, Huber O, Kemler R (Dec 1998). "Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14787–92. doi:10.1073/pnas.95.25.14787. PMC 24527Freely accessible. PMID 9843967. 
  7. ^ a b Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (August 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi:10.1016/s0092-8674(01)00450-0. PMID 11509179. 
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931. 

Further reading[edit]