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Assisted reproductive technology
Assisted reproductive technology (ART) is the use of reproductive technology to treat low fertility or infertility. ART is currently the only form of reproductive technology in clinical use, and is more effective in those suffering from ovulatory disorders or endometriosis (those without a functional uterus, for example, for the time being can only conceive through surrogacy methods). Examples of ART include in vitro fertilization and its possible expansions, including:
- artificial insemination
- artificial reproduction
- cloning (see human cloning for the special case of human beings)
- cytoplasmic transfer
- cryopreservation of sperm, oocytes, embryos
- embryo transfer
- fertility medication
- hormone treatment
- in vitro fertilization
- in vitro generated gametes
- preimplantation genetic diagnosis
Reproductive technology can inform family planning by providing individual prognoses regarding the likelihood of pregnancy. It facilitates the monitoring of ovarian reserve, follicular dynamics and associated biomarkers in females, and semen analysis in males.
Contraception is a form of reproductive technology that enables people to control their fertility.
The following reproductive techniques are not currently in routine clinical use; most are still undergoing development:
Research is currently investigating the possibility of same-sex procreation, which would produce offspring with equal genetic contributions from either two females or two males. This form of reproduction has become a possibility through the creation of either female sperm (containing the genetic material of a female) or male eggs (containing the genetic material of a male). Same-sex procreation would remove the need for lesbian and gay couples to rely on a third party donation of a sperm or an egg for reproduction.
The first significant development occurred in 1991, in a patent application filed by U.Penn. scientists to fix male sperm by extracting some sperm, correcting a genetic defect in vitro, and injecting the sperm back into the male's testicles. While the vast majority of the patent application dealt with male sperm, one line suggested that the procedure would work with XX cells, i.e., cells from an adult woman to make female sperm.
In the two decades that followed, the idea of female sperm became more of a reality. In 1997, scientists partially confirmed such techniques by creating chicken female sperm in a similar manner. They did so by injecting blood stem cells from an adult female chicken into a male chicken's testicles. In 2004, other Japanese scientists created two female offspring by combining the eggs of two adult mice.
In 2008, research was done specifically for methods on creating human female sperm using artificial or natural Y chromosomes and testicular transplantation. A UK-based group predicted they would be able to create human female sperm within five years. So far no conclusive successes have been achieved.
In 2018 Chinese research scientists produced 29 viable mice offspring from two mother mice by creating sperm-like structures from haploid Embryonic stem cells using gene editing to alter imprinted regions of DNA. They were unable to get viable offspring from two fathers. Experts noted that there was little chance of these techniques being applied to humans in the near future.
Many issues of reproductive technology have given rise to bioethical issues, since technology often alters the assumptions that lie behind existing systems of sexual and reproductive morality. Other ethical considerations arise with the application of ART to women of advanced maternal age, who have higher changes of medical complications (including pre-eclampsia), and possibly in the future its application to post-menopausal women.
Also, ethical issues of human enhancement arise when reproductive technology has evolved to be a potential technology for not only reproductively inhibited people but even for otherwise reproductively healthy people.
See individual subarticles for details
- Films and other fiction depicting contemporary emotional struggles of assisted reproductive technology have had an upswing first in the latter part of the 2000s decade, although the techniques have been available for decades. Yet, the number of people that can relate to it
- Science fiction has tackled the themes of creating life through other than the conventional methods since Mary Shelley's Frankenstein. In the 20th century, Aldous Huxley's Brave New World (1932) was the first major fictional work to anticipate the possible social consequences of reproductive technology. Its largely negative view was reversed when the author revisited the same themes in his utopian final novel, Island (1962).
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- Li, Zhi-Kun; Wang, Le-Yun; Wang, Li-Bin; Feng, Gui-Hai; Yuan, Xue-Wei; Liu, Chao; Xu, Kai; Li, Yu-Huan; Wan, Hai-Feng (1 October 2018). "Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions". Cell Stem Cell. doi:10.1016/j.stem.2018.09.004. ISSN 1934-5909.
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- Colleen Mastony (21 June 2009). "Heartache of infertility shared on stage, screen". Chicago Tribune.