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Protein-coding gene in the species Homo sapiens
Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene .[ 5]
The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins . This family contains proteins that are related to Drosophila rhomboid-1 . Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases .
RHBDL2 functions as a sheddase and is localized to the plasma membrane .[ 6] thrombomodulin and epidermal growth factor ;[ 6] type I membrane proteins substrates, including BCAM , SPINT1 , and CLCP1 .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000158315 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043333 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)" .^ a b Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018). "Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments" . The EMBO Journal . 37 (15). doi :10.15252/embj.201899456 . PMC 6068445 PMID 29976761 . ^ Johnson N, Březinová J, Stephens E, Burbridge E, Freeman M, Adrain C, Strisovsky K (August 2017). "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis" . Scientific Reports . 7 (1): 7283. Bibcode :2017NatSR...7.7283J . doi :10.1038/s41598-017-07556-3 . PMC 5544772 PMID 28779096 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
