|Name(s)||T102C, 102T/C, C102T, 102C/T, g.102T>C|
In genetics, rs6313 also called T102C or C102T is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor. The SNP is a synonymous substitution located in exon 1 of the gene where it is involved in coding the 34th amino acid as serine.
As 5-HT2A is a neuroreceptor the SNP has been investigated in connection with brain functions and neuropsychiatric disorders, and it is perhaps the most investigated SNP for its gene. Two other SNPs in HTR2A have also received much attention: rs6311 and His452Tyr (rs6314). The T102C polymorphism has been shown to be in complete linkage disequilibrium with the rs6311 (A-1438G).  A less well investigated SNP of this gene is rs7997012.
Meta-analyses seem to indicate that the SNP is not directly associated with schizophrenia, not with Alzheimer's Disease, and two initial studies seem to indicate that it is not associated with Parkinson's Disease.
The C-allele has been associated with higher extraversion personality scores among borderline personality disorder  patients and the presence of visual and auditory hallucinations in patients with Late-onset Alzheimer's Disease.  Multiple studies have found that individuals with schizophrenia who are homozygous for the C-allele tend to do worse on working memory tasks than do individuals with a T-allele.    Rs6313 has also been shown to be associated with novelty seeking among Italian mood disorder patients  and reward dependence in a German population.  The SNP may also be associated with rheumatoid arthritis.  One study found no association between the SNP and suicidal behavior in a Chinese population,  and another found no association with fibromyalgia syndrome. 
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- Xingqun Ni, Ramprasad Bismil, Kirsten Chan, Tricia Sicard, Natalie Bulgin, Shelley McMain and James L. Kennedy (November 2006). "Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder". Neuroscience Letters. 408 (3): 214–219. doi:10.1016/j.neulet.2006.09.002. PMID 17000047.
- Clive Holmes, Maria J. Arranz, John F. Powell, David A. Collier and Simon Lovestone (1998). "5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease". Human Molecular Genetics. 7 (9): 1507–1509. doi:10.1093/hmg/7.9.1507. PMID 9700207.
- Alfimova, M. V., Monakhov, M. V., Abramova, L. I., Golubev, S. A., & Golimbet, V. E. (2012). "Polymorphism of serotonin receptor genes (5-HTR2A) and dysbindin (DTNBP1) and individual components of short-term verbal memory processes in schizophrenia.". Neuroscience and Behavioral Physiology. 40 (8): 934–940. doi:10.1007/s11055-010-9348-7.
- Golimbet, V. E., Alfimova, M. V., Kaleda, V. G., Abramova, L. I., Korovaitseva, G. I., Lavrushina, O. M.; et al. (2009). "Schizoaffective psychosis and schizophrenia with- or without affective syndrome: A comparative clinical, neuropsychological and molecular-genetic study.". NOVA Science: 70–87.
- Gong, P., Li, J., Wang, J., Lei, X., Chen, D., Zhang, K.; et al. (2011). "Variations in 5-HT2A influence spatial cognitive abilities and working memory.". Canadian Journal of Neurological Sciences. 38: 303–308.
- Alessandro Serretti, Raffaella Calati, Ina Giegling, Annette M. Hartmann, Hans-Jürgen Möller, Cristina Colombo and Dan Rujescu (August 2007). "5-HT2A SNPs and the Temperament and Character Inventory". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31 (6): 1275–1281. doi:10.1016/j.pnpbp.2007.05.008. PMID 17590256.
- Paul G. Unschuld, Marcus Ising, Angelika Erhardt, Susanne Lucae, Stefan Kloiber, Martin Kohli, Daria Salyakina, Tobias Welt, Nikola Kern, Roselind Lieb, Manfred Uhr, Elisabeth B. Binder, Bertram Müller-Myhsok, Florian Holsboer, Martin E. Keck (2007). "Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder". American Journal of Medical Genetics Part B. 144B (4): 424–429. doi:10.1002/ajmg.b.30412. PMID 17440930.
- Anders Kling, Maria Seddighzadeh, Lisbeth Ärlestig, Lars Alfredsson, Solbritt Rantapaa-Dahlqvist and Leonid Padyukov (November 2007). "Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis". Ann Rheum Dis. 67 (8): 1111–5. doi:10.1136/ard.2007.074948. PMID 18006541.
- Jing Zhang, Yifeng Shen, Guang He, Xingwang Li, Junwei Meng, Shengzhen Guo, Huafang Li, Niufan Gu, Guoyin Feng and Lin He (February 2008). "Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32 (2): 467–471. doi:10.1016/j.pnpbp.2007.09.019. PMID 17964050.
- Berna Tander, Sezgin Gunes, Omer Boke, Gamze Alayli, Nurten Kara, Hasan Bagci and Ferhan Canturk (May 2008). "Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility". Rheumatology International. 28 (7): 685–691. doi:10.1007/s00296-008-0525-8. PMID 18196244.
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