Brandon was first named to a high-level executive position within the franchise in 2006, being named director of non-football operations alongside general managerMarv Levy. Brandon, although his title did not change, assumed Levy's responsibilities as de facto general manager after Levy retired. Brandon was promoted to CEO upon the hiring of Buddy Nix as the Bills general manager.
Among other things, he is credited with expanding the Buffalo Bills fan base throughout the Western New York/Southern Ontario region, and was instrumental in the deal for the Bills to play two games per season (one pre-season, one regular season) in Toronto, Canada, which many football fans have regarded as a sacrifice of home field advantage in favor of revenue. An influential NFL executive, Brandon also serves on several league business and marketing committees.
As CEO, Brandon increased his influence on the team and handled most of its day-to-day operations while owner Ralph Wilson's health began to decline. This culminated in Wilson officially naming Brandon as President on January 1, 2013, giving Brandon full control over the franchise. Brandon is only the third person to serve as President of the Bills, after Wilson and Tom Donahoe.
Since Wilson's retirement, Brandon had served as the team's representative in owner's meetings in lieu of Wilson, a position he continued even as his widow inherited the trust that held ownership of the team.