S100A8

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S100A8
Protein S100A8 PDB 1mr8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8
External IDs MGI: 88244 HomoloGene: 2225 GeneCards: S100A8
RNA expression pattern
PBB GE S100A8 202917 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002964
NM_001319196
NM_001319197
NM_001319198
NM_001319201

NM_013650

RefSeq (protein)

NP_001306125
NP_001306126
NP_001306127
NP_001306130
NP_002955

NP_038678.1
NP_038678

Location (UCSC) Chr 1: 153.39 – 153.39 Mb Chr 3: 90.67 – 90.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.[3] It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.[3]

References[edit]

Further reading[edit]