SAV1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SAV1
Protein SAV1 PDB 2dwv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SAV1, SAV, WW45, WWP4, salvador family WW domain containing protein 1
External IDs MGI: 1927144 HomoloGene: 32517 GeneCards: SAV1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021818

NM_022028

RefSeq (protein)

NP_068590

NP_071311.1
NP_071311

Location (UCSC) Chr 14: 50.63 – 50.67 Mb Chr 12: 69.97 – 69.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.[3][4][5]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK (Aug 2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell. 110 (4): 467–78. doi:10.1016/S0092-8674(02)00824-3. PMID 12202036. 
  4. ^ Valverde P (Oct 2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene". Biochem Biophys Res Commun. 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID 11027580. 
  5. ^ a b "Entrez Gene: SAV1 salvador homolog 1 (Drosophila)". 

Further reading[edit]