SELT

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SELENOT
Identifiers
AliasesSELENOT, SELT, selenoprotein T
External IDsMGI: 1916477 HomoloGene: 32304 GeneCards: SELENOT
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SELENOT
Genomic location for SELENOT
Band3q25.1Start150,602,875 bp[1]
End150,630,445 bp[1]
RNA expression pattern
PBB GE SELT 217811 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016275

NM_001040396

RefSeq (protein)

NP_057359

NP_001035486

Location (UCSC)Chr 3: 150.6 – 150.63 MbChr 3: 58.58 – 58.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.[5][6][7]

Gene[edit]

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[7]

Protein structure[edit]

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198843 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075700 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
  6. ^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843.
  7. ^ a b "Entrez Gene: SELT selenoprotein T".

Further reading[edit]