SEPTIN1

SEPTIN1
Identifiers
Aliases	SEPTIN1, DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDs	OMIM: 612897; MGI: 1858916; HomoloGene: 23009; GeneCards: SEPTIN1; OMA:SEPTIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,395,991 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,832,302 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; appendix; ; spleen; ; lymph node; ; thymus; ; blood; ; bone marrow cells; ; mucosa of transverse colon; ; rectum; ; sural nerve;
	Top expressed in
	granulocyte; ; thymus; ; ventricular zone; ; blood; ; blastocyst; ; morula; ; spleen; ; neural layer of retina; ; lymph node; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; identical protein binding; GTPase activity; molecular adaptor activity;
Cellular component	cytoplasm; cytoskeleton; microtubule organizing center; midbody; septin ring; synaptic vesicle; microtubule cytoskeleton; septin complex; septin filament array;
Biological process	cell division; cell cycle; mitotic cytokinesis; septin ring assembly; regulation of exocytosis; cilium assembly; cytoskeleton-dependent cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	1731
	54204
	ENSG00000180096
	ENSMUSG00000000486
	Q8WYJ6
	P42209
	NM_052838; NM_001365977
	NM_017461
	NP_443070; NP_001352906
	NP_059489
	Wikidata
View/Edit Human	View/Edit Mouse

Septin-1 is a protein that in humans is encoded by the SEPT1 gene.^[5]^[6]

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180096 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000486 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
^ ^a ^b "Entrez Gene: SEPT1 septin 1".

Nottenburg C, Gallatin WM, St John T (November 1990). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences". Gene. 95 (2): 279–84. doi:10.1016/0378-1119(90)90372-X. PMID 2174398.
Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (November 1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease". The American Journal of Pathology. 153 (5): 1551–60. doi:10.1016/S0002-9440(10)65743-4. PMC 1853406. PMID 9811347.
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L (October 2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 (3): 994–1000. doi:10.1016/j.bbrc.2005.06.212. PMID 16179162.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (November 2007). "Overexpression of Septin1: possible contribution to the development of oral cancer". International Journal of Oncology. 31 (5): 1021–8. doi:10.3892/ijo.31.5.1021. PMID 17912427.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180096 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000486 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8697812-5] Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.

[entrez-6] "Entrez Gene: SEPT1 septin 1".

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Function

References

Further reading