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SEPTIN1

From Wikipedia, the free encyclopedia

SEPTIN1
Identifiers
AliasesSEPTIN1, DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDsOMIM: 612897; MGI: 1858916; HomoloGene: 23009; GeneCards: SEPTIN1; OMA:SEPTIN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052838
NM_001365977

NM_017461

RefSeq (protein)

NP_443070
NP_001352906

NP_059489

Location (UCSC)Chr 16: 30.38 – 30.4 MbChr 7: 126.81 – 126.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene.[5][6] It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.[7]

Function

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This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180096Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000486Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
  6. ^ a b "Entrez Gene: SEPT1 septin 1".
  7. ^ Vincent J (6 August 2020). "Scientists rename human genes to stop Microsoft Excel from misreading them as dates". the Verge. Retrieved 2022-10-24.

Further reading

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