SESN1

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SESN1
Identifiers
AliasesSESN1, PA26, SEST1, sestrin 1
External IDsOMIM: 606103 MGI: 2155278 HomoloGene: 8697 GeneCards: SESN1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SESN1
Genomic location for SESN1
Band6q21Start108,986,437 bp[1]
End109,094,819 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014454
NM_001199933
NM_001199934

NM_001013370
NM_001162908

RefSeq (protein)

NP_001186862
NP_001186863
NP_055269

NP_001013388
NP_001156380

Location (UCSC)Chr 6: 108.99 – 109.09 MbChr 10: 41.81 – 41.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6][7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080546 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038332 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: sestrin 1".
  6. ^ Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
  7. ^ Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

Further reading[edit]

  • Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (April 2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596–600. doi:10.1126/science.1095569. PMID 15105503.
  • Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (May 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115.