SH2D1B

SH2D1B
Identifiers
Aliases	SH2D1B, EAT2, SH2 domain containing 1B
External IDs	OMIM: 608510; MGI: 1349420; HomoloGene: 8070; GeneCards: SH2D1B; OMA:SH2D1B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,412,138 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	170,114,338 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; gastrocnemius muscle; ; blood; ; testicle; ; sperm; ; muscle of thigh; ; monocyte; ; amniotic fluid; ; deltoid muscle; ; spleen;
	Top expressed in
	spleen; ; granulocyte; ; lung; ; jejunum; ; bone marrow; ; ileum; ; choroid plexus; ; prefrontal cortex; ; medulla oblongata; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding;
Cellular component	cytosol; intracellular anatomical structure;
Biological process	innate immune response; leukocyte activation involved in immune response; adaptive immune response; positive regulation of natural killer cell mediated immunity; positive regulation of innate immune response; regulation of immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	117157
	26904
	ENSG00000198574
	ENSMUSG00000102418
	O14796
	O35324; Q149T1
	NM_053282
	NM_012009
	NP_444512
	NP_036139
	Wikidata
View/Edit Human	View/Edit Mouse

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.^[5]^[6]^[7]

Interactions

SH2D1B has been shown to interact with SLAMF1.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198574 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000102418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene. 13 (12): 2649–58. PMID 9000139.
^ ^a ^b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
^ "Entrez Gene: SH2D1B SH2 domain containing 1B".