SHC3

SHC3
Identifiers
Aliases	SHC3, N-Shc, NSHC, RAI, SHCC, SHC adaptor protein 3
External IDs	OMIM: 605263; MGI: 106179; HomoloGene: 7536; GeneCards: SHC3; OMA:SHC3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,178,818 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	51,723,523 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; orbitofrontal cortex; ; frontal pole; ; dorsolateral prefrontal cortex; ; Brodmann area 46;
	Top expressed in
	superior frontal gyrus; ; superior surface of tongue; ; gallbladder; ; secondary oocyte; ; morula; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; cingulate gyrus; ; entorhinal cortex; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor tyrosine kinase binding; signal transducer activity; protein binding; phosphotyrosine residue binding;
Cellular component	cytosol; plasma membrane; cellular component;
Biological process	intracellular signal transduction; epidermal growth factor receptor signaling pathway; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase signaling pathway; MAPK cascade; central nervous system development; learning or memory; Ras protein signal transduction; signal transduction; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	53358
	20418
	ENSG00000148082
	ENSMUSG00000021448
	Q92529
	Q61120
	NM_016848
	NM_009167
	NP_058544
	NP_033193
	Wikidata
View/Edit Human	View/Edit Mouse

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.^[5]^[6]

Template:PBB Summary

Interactions

SHC3 has been shown to interact with RICS^[7] and TrkB.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148082 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021448 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
^ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
^ Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. 22 (24). United States: 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. 273 (12). UNITED STATES: 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. 294 (5). United States: 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading