SOX2OT

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SOX2-OT
Identifiers
Aliases SOX2-OT, NCRNA00043, SOX2-OT, SOX2 overlapping transcript
External IDs GeneCards: SOX2-OT
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SOX2-OT
Genomic location for SOX2-OT
Band 3q26.33 Start 180,989,770 bp[1]
End 181,836,880 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC) Chr 3: 180.99 – 181.84 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies within one of the introns of SOX2OT.[3] SOX2OT and SOX2DOT (an isoform of SOXOT transcribed from a distal highly conserved element) are expressed in zones of neurogenesis within the brain. It is associated with central nervous system structures in zebrafish and chicken embryonic brains, and is dynamically regulated during embryogenesis.[4] SOX2OT may play a role in vertebrate development.[4]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242808 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Fantes J, Ragge NK, Lynch SA, et al. (April 2003). "Mutations in SOX2 cause anophthalmia". Nat. Genet. 33 (4): 461–3. PMID 12612584. doi:10.1038/ng1120. 
  4. ^ a b Amaral PP, Neyt C, Wilkins SJ, et al. (November 2009). "Complex architecture and regulated expression of the Sox2ot locus during vertebrate development". RNA. 15 (11): 2013–27. PMC 2764477Freely accessible. PMID 19767420. doi:10.1261/rna.1705309. 

Further reading[edit]