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Protein SPEN PDB 1ow1.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesSPEN, HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor
External IDsMGI: 1891706 HomoloGene: 124461 GeneCards: SPEN
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SPEN
Genomic location for SPEN
Band1p36.21-p36.13Start15,847,864 bp[1]
End15,940,460 bp[1]
RNA expression pattern
PBB GE SPEN 201997 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 15.85 – 15.94 MbChr 4: 141.47 – 141.54 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.[5][6][7]

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.[7]


SPEN has been shown to interact with HDAC1,[6] SRA1[6] and Nuclear receptor co-repressor 2.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065526 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040761 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Newberry EP, Latifi T, Towler DA (Sep 1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter". Biochemistry. 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.
  6. ^ a b c d Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
  7. ^ a b "Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)".

Further reading[edit]