Nuclear receptor co-repressor 2

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NCOR2
Protein NCOR2 PDB 1xc5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
External IDs OMIM: 600848 MGI: 1337080 HomoloGene: 31370 GeneCards: NCOR2
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NCOR2
Genomic location for NCOR2
Band 12q24.31 Start 124,324,415 bp[1]
End 124,567,589 bp[1]
RNA expression pattern
PBB GE NCOR2 208888 s at fs.png

PBB GE NCOR2 207760 s at fs.png

PBB GE NCOR2 208889 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006312
NM_001077261
NM_001206654

NM_001253904
NM_001253905
NM_011424

RefSeq (protein)

NP_001070729
NP_001193583
NP_006303
NP_001193583.1

NP_001240833
NP_001240834
NP_035554

Location (UCSC) Chr 12: 124.32 – 124.57 Mb Chr 12: 125.02 – 125.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[5][6] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[5] or T3 receptor-associating cofactor 1 (TRAC-1).[6]

Function[edit]

NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.[5] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[7]

Family[edit]

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.[8]

Discovery[edit]

SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[5] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[6]

Interactions[edit]

Nuclear receptor co-repressor 2 has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196498 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029478 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b c d Chen JD, Evans RM (October 1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127. 
  6. ^ a b c Sande S, Privalsky ML (July 1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Molecular Endocrinology. 10 (7): 813–25. doi:10.1210/me.10.7.813. PMID 8813722. 
  7. ^ Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM (May 1997). "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase". Cell. 89 (3): 373–80. doi:10.1016/S0092-8674(00)80218-4. PMID 9150137. 
  8. ^ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
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  25. ^ Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A (July 2013). "Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor". Nature Neuroscience. 16 (7): 898–902. doi:10.1038/nn.3434. PMC 3786392Freely accessible. PMID 23770565. 
  26. ^ Sohn YC, Kwak E, Na Y, Lee JW, Lee SK (November 2001). "Silencing mediator of retinoid and thyroid hormone receptors and activating signal cointegrator-2 as transcriptional coregulators of the orphan nuclear receptor Nur77". The Journal of Biological Chemistry. 276 (47): 43734–9. doi:10.1074/jbc.M107208200. PMID 11559707. 
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Further reading[edit]


External links[edit]