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SSX6

From Wikipedia, the free encyclopedia
SSX6P
Identifiers
AliasesSSX6P, SSXP2, SSX family member 6, pseudogene, SSX6, dJ54B20.1, psiSSX2, synovial sarcoma, X breakpoint 6 (pseudogene)
External IDsOMIM: 300541; GeneCards: SSX6P; OMA:SSX6P - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173357

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene. [2]

Function

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This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy.

SSX1, SSX2, and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene is classified as a pseudogene because a splice donor in the 3' UTR has changed compared to other family members, rendering the transcript a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Aug 2009].

References

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  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Entrez Gene: SSX family member 6, pseudogene". Retrieved 2017-12-11.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.