Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5gene.[5][6] ST5 orthologs[7] have been identified in nearly all mammals for which complete genome data are available.
Function
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lichy JH, Modi WS, Seuanez HN, Howley PM (August 1992). "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells". Cell Growth & Differentiation. 3 (8): 541–8. PMID1390339.
Majidi M, Hubbs AE, Lichy JH (June 1998). "Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5". The Journal of Biological Chemistry. 273 (26): 16608–14. doi:10.1074/jbc.273.26.16608. PMID9632734.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Hubbs AE, Majidi M, Lichy JH (April 1999). "Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology". Oncogene. 18 (15): 2519–25. doi:10.1038/sj.onc.1202554. PMID10229203.
Majidi M, Gutkind JS, Lichy JH (March 2000). "Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells". The Journal of Biological Chemistry. 275 (9): 6560–5. doi:10.1074/jbc.275.9.6560. PMID10692462.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Amid C, Bahr A, Mujica A, Sampson N, Bikar SE, Winterpacht A, Zabel B, Hankeln T, Schmidt ER (2001). "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7". Cytogenetics and Cell Genetics. 93 (3–4): 284–90. doi:10.1159/000056999. PMID11528127.
