From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene .[ 5] This enzyme adds a N -acetylneuraminic acid (Neu5Ac, a sialic acid ) to an O-linked N-acetylgalactosamine (GalNAc) on a peptide/proteins (also called Tn antigen ) with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers threonine over serine containing GalNAc residues.[ 6] [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000070526 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009588 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1" .
^ Mehta AY, Veeraiah RK, Dutta S, Goth CK, Hanes MS, Gao C, et al. (June 2020). "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries" . Cell Chemical Biology . 27 (9): 1207–1219.e9. doi :10.1016/j.chembiol.2020.06.007 . PMC 7556346 . PMID 32610041 .
^ Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, et al. (November 2019). "Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies" . Scientific Reports . 9 (1): 16641. Bibcode :2019NatSR...916641Y . doi :10.1038/s41598-019-53052-1 . PMC 6851390 . PMID 31719620 .
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Ikehara Y, Kojima N, Kurosawa N, Kudo T, Kono M, Nishihara S, Issiki S, Morozumi K, Itzkowitz S, Tsuda T, Nishimura SI, Tsuji S, Narimatsu H (November 1999). "Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens" . Glycobiology . 9 (11): 1213–24. doi :10.1093/glycob/9.11.1213 . PMID 10536037 .
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Julien S, Krzewinski-Recchi MA, Harduin-Lepers A, Gouyer V, Huet G, Le Bourhis X, Delannoy P (2003). "Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA". Glycoconjugate Journal . 18 (11–12): 883–93. doi :10.1023/A:1022200525695 . PMID 12820722 . S2CID 21051703 .
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Sewell R, Bäckström M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, Gätgens J, Clausen H, Hansson GC, Burchell J, Taylor-Papadimitriou J (February 2006). "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer" . The Journal of Biological Chemistry . 281 (6): 3586–94. doi :10.1074/jbc.M511826200 . PMID 16319059 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .