STAB1

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STAB1
Identifiers
AliasesSTAB1, CLEVER-1, FEEL-1, FELE-1, FEX1, STAB-1, SCARH2, stabilin 1
External IDsOMIM: 608560 MGI: 2178742 HomoloGene: 9035 GeneCards: STAB1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for STAB1
Genomic location for STAB1
Band3p21.1Start52,495,338 bp[1]
End52,524,495 bp[1]
RNA expression pattern
PBB GE STAB1 204150 at fs.png

PBB GE STAB1 38487 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015136

NM_138672

RefSeq (protein)

NP_055951

n/a

Location (UCSC)Chr 3: 52.5 – 52.52 MbChr 14: 31.14 – 31.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.[5][6][7]

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.[7] STAB1 is also known to interact with the protein chitinase domain-containing protein 1.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010327 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042286 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S (Feb 2002). "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues". Biochem J. 362 (Pt 1): 155–64. doi:10.1042/0264-6021:3620155. PMC 1222372. PMID 11829752.
  6. ^ Adachi H, Tsujimoto M (Sep 2002). "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities". J Biol Chem. 277 (37): 34264–70. doi:10.1074/jbc.M204277200. PMID 12077138.
  7. ^ a b "Entrez Gene: STAB1 stabilin 1".

Further reading[edit]