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Aliases SURF4, ERV29, surfeit 4
External IDs MGI: 98445 HomoloGene: 6052 GeneCards: SURF4
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 9: 133.36 – 133.38 Mb Chr 2: 26.92 – 26.93 Mb
PubMed search [1] [2]
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Surfeit locus protein 4 is a protein that in humans is encoded by the SURF4 gene.[3][4][5]

This gene is located in the surfeit gene cluster, which is composed of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yon J, Jones T, Garson K, Sheer D, Fried M (Jun 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum Mol Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913. 
  4. ^ Reeves JE, Fried M (Aug 1995). "The surf-4 gene encodes a novel 30 kDa integral membrane protein". Mol Membr Biol. 12 (2): 201–8. doi:10.3109/09687689509027508. PMID 7540914. 
  5. ^ a b "Entrez Gene: SURF4 surfeit 4". 

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