SYVN1

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SYVN1
Identifiers
Aliases SYVN1, DER3, HRD1, synoviolin 1
External IDs MGI: 1921376 HomoloGene: 32700 GeneCards: SYVN1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032431
NM_172230

NM_001164709
NM_028769

RefSeq (protein)

NP_115807
NP_757385

NP_001158181.1
NP_083045.4
NP_001158181
NP_083045

Location (UCSC) Chr 11: 65.12 – 65.13 Mb Chr 19: 6.05 – 6.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase synoviolin is an enzyme that in humans is encoded by the SYVN1 gene.[3][4]

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence. Sequence analysis identified two transcript variants that encode different isoforms.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T (Oct 2003). "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy". Genes Dev. 17 (19): 2436–49. doi:10.1101/gad.1096603. PMC 218080Freely accessible. PMID 12975321. 
  4. ^ a b "Entrez Gene: SYVN1 synovial apoptosis inhibitor 1, synoviolin". 

Further reading[edit]