SYVN1

SYVN1
Identifiers
Aliases	SYVN1, DER3, HRD1, synoviolin 1
External IDs	OMIM: 608046; MGI: 1921376; HomoloGene: 32700; GeneCards: SYVN1; OMA:SYVN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,134,532 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,103,742 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; body of pancreas; ; right lobe of liver; ; bone marrow cells; ; appendix; ; stromal cell of endometrium; ; islet of Langerhans; ; right lobe of thyroid gland; ; lymph node; ; left lobe of thyroid gland;
	Top expressed in
	mesenteric lymph nodes; ; lacrimal gland; ; salivary gland; ; decidua; ; left lobe of liver; ; islet of Langerhans; ; molar; ; spleen; ; seminal vesicula; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	chaperone binding; unfolded protein binding; ATPase binding; metal ion binding; protein binding; ubiquitin-specific protease binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; nucleoplasm; smooth endoplasmic reticulum; integral component of endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; Derlin-1 retrotranslocation complex; Hrd1p ubiquitin ligase complex; Hrd1p ubiquitin ligase ERAD-L complex; membrane; endoplasmic reticulum;
Biological process	protein stabilization; protein K48-linked ubiquitination; retrograde protein transport, ER to cytosol; IRE1-mediated unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein N-linked glycosylation via asparagine; endoplasmic reticulum mannose trimming; ERAD pathway; endoplasmic reticulum unfolded protein response; ubiquitin-dependent ERAD pathway; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	84447
	74126
	ENSG00000162298
	ENSMUSG00000024807
	Q86TM6
	Q9DBY1
	NM_032431; NM_172230
	NM_001164709; NM_028769
	NP_115807; NP_757385
	NP_001158181; NP_083045
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase synoviolin is an enzyme that in humans is encoded by the SYVN1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024807 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T (Oct 2003). "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy". Genes Dev. 17 (19): 2436–49. doi:10.1101/gad.1096603. PMC 218080. PMID 12975321.
^ "Entrez Gene: SYVN1 synovial apoptosis inhibitor 1, synoviolin".

References

Further reading