After graduation, Lotti moved to Los Angeles and attended the University of Southern California (USC). In addition to her regular classes, Lotti studied with highly regarded Hollywood acting coach, Ivana Chubbuck. Lotti also informally studied music and singing for numerous years, showing a particularly strong passion and talent for blues and jazz music.
Lotti acted in a series of independent films including, Lover Girl, starring Sandra Bernhard and Tara Subkoff. In 2001 she produced, wrote, directed and acted in a short comedy film called, Sluts and Losers, also starring Ashley Hamilton (son of George Hamilton and the stepson of Rod Stewart). The film was co-executive produced by Balthazar Getty.
According to The Hollywood Reporter, in March 2006, Lotti signed a two picture comedy deal with 20th Century Fox. Lotti caught the eye of Fox's President, Debbie Liebling (the executive responsible for the Sacha Baron Cohen smash comedy hit, Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan, as well as Comedy Central's South Park), after Liebling read her script, A Family Affair.
In March 2006 she sold the comedy pitch WishBoned (aka Dear God It's Me Rod) to 20th Century Fox. WishBoned is being produced by Andrew Gunn, producer of the Disney hit, Freaky Friday. Just one week later Lotti sold 20th Century Fox the project, Back Magick. Shawn Levy (director of Night at the Museum) is attached to produce.
In June 2010, The Hollywood Reporter announces that Lotti has been hired by CBS Films to adapt British best-seller "The Ex Files".
She is represented by International Creative Management (ICM).
- July 2010 - 'CBS Films Thinks Brit Novel Has Ex Factor' Deadline
- June 2010 - 'Writer Sahara Lotti hooking up with ‘Exes’ for CBS Films' 
- March 2006 - 'Fox Loves Sahara Lotti' Cinematical
- June 2006 - 'Affair' flair for New Line' Variety
- Universal Pictures picks up Freaks of the Jungle - Literary Sales
- Back Magick for Sahara Lotti & Shawn Levy Backstage 
- Lover Girl Review - New York Times