At the beginning of 2001, the second phase of the Caracas line of the system was opened from Tercer Milenio to the intermediate station Calle 40 Sur. A few months later, service was extended south to Portal de Usme.
The station is named Santa Lucía for the neighborhood of the same name located to the west of the station.
On January 6, 2003, an incendiary device exploded near this station. In 2004, three people were injured by shrapnel from a bomb that exploded on a bus that was on the route with Caracas at Calle 47 Sur, one block from the station.
