Serglycin

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SRGN
Identifiers
AliasesSRGN, PPG, PRG, PRG1, serglycin
External IDsOMIM: 177040 HomoloGene: 2043 GeneCards: SRGN
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SRGN
Genomic location for SRGN
Band10q22.1Start69,088,103 bp[1]
End69,104,805 bp[1]
RNA expression pattern
PBB GE SRGN 201859 at fs.png

PBB GE SRGN 201858 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002727
NM_001321053
NM_001321054

n/a

RefSeq (protein)

NP_001307982
NP_001307983
NP_002718

n/a

Location (UCSC)Chr 10: 69.09 – 69.1 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Serglycin, also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.[3] It is primarily expressed in hematopoietic cells and endothelial cells,[4] and is the only known intracellular proteoglycan.[5]

Function[edit]

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.[3]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122862 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: SRGN serglycin".
  4. ^ Kolset SO, Tveit H (April 2008). "Serglycin--structure and biology". Cellular and Molecular Life Sciences. 65 (7–8): 1073–85. doi:10.1007/s00018-007-7455-6. PMID 18066495.
  5. ^ Iozzo RV, Schaefer L (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix Biology. 42: 11–55. doi:10.1016/j.matbio.2015.02.003. PMC 4859157. PMID 25701227.

Further reading[edit]