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Protein PPP1R9B PDB 2g5m.png
Aliases PPP1R9B, PPP1R6, PPP1R9, SPINO, Spn, protein phosphatase 1 regulatory subunit 9B
External IDs MGI: 2387581 HomoloGene: 32787 GeneCards: PPP1R9B
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for PPP1R9B
Genomic location for PPP1R9B
Band 17q21.33 Start 50,133,735 bp[1]
End 50,150,630 bp[1]
RNA expression pattern
PBB GE PPP1R9B gnf1h00839 at fs.png

PBB GE PPP1R9B gnf1h00838 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 50.13 – 50.15 Mb Chr 17: 94.99 – 95.01 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.[5][6]

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM][6]


PPP1R9B has been shown to interact with PPP1CB,[7] PPP1CA,[7] Dopamine receptor D2,[8] P16,[9] PPP1CC,[7][8] T-cell lymphoma invasion and metastasis-inducing protein 1[10] and PPP1R2.[11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108819 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038976 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Allen PB, Ouimet CC, Greengard P (Oct 1997). "Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines". Proc Natl Acad Sci U S A. 94 (18): 9956–61. PMC 23308Freely accessible. PMID 9275233. doi:10.1073/pnas.94.18.9956. 
  6. ^ a b "Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B". 
  7. ^ a b c Hsieh-Wilson, L C; Allen P B; Watanabe T; Nairn A C; Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. UNITED STATES. 38 (14): 4365–73. ISSN 0006-2960. PMID 10194355. doi:10.1021/bi982900m. 
  8. ^ a b Smith, F D; Oxford G S; Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. UNITED STATES. 274 (28): 19894–900. ISSN 0021-9258. PMID 10391935. doi:10.1074/jbc.274.28.19894. 
  9. ^ Vivo, M; Calogero R A; Sansone F; Calabrò V; Parisi T; Borrelli L; Saviozzi S; La Mantia G (Apr 2001). "The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein". J. Biol. Chem. United States. 276 (17): 14161–9. ISSN 0021-9258. PMID 11278317. doi:10.1074/jbc.M006845200. 
  10. ^ Buchsbaum, Rachel J; Connolly Beth A; Feig Larry A (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. United States. 278 (21): 18833–41. ISSN 0021-9258. PMID 12531897. doi:10.1074/jbc.M207876200. 
  11. ^ Terry-Lorenzo, Ryan T; Elliot Elizabeth; Weiser Douglas C; Prickett Todd D; Brautigan David L; Shenolikar Shirish (Nov 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. United States. 277 (48): 46535–43. ISSN 0021-9258. PMID 12270929. doi:10.1074/jbc.M206960200. 

Further reading[edit]