Synaptogyrin 3

SYNGR3
Identifiers
Aliases	SYNGR3, synaptogyrin 3
External IDs	OMIM: 603927; MGI: 1341881; HomoloGene: 3101; GeneCards: SYNGR3; OMA:SYNGR3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,994,275 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,908,929 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; superior frontal gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; Pons; ; primary visual cortex; ; entorhinal cortex; ; dorsolateral prefrontal cortex; ; frontal pole;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; dorsomedial hypothalamic nucleus; ; nucleus of stria terminalis; ; ventral tegmental area; ; piriform cortex; ; medial dorsal nucleus; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH2 domain binding; protein N-terminus binding;
Cellular component	cell junction; integral component of membrane; cytoplasmic vesicle; synapse; synaptic vesicle; membrane; neuromuscular junction; synaptic vesicle membrane;
Biological process	substantia nigra development; positive regulation of transporter activity; regulated exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	9143
	20974
	ENSG00000127561
	ENSMUSG00000007021
	O43761
	Q8R191
	NM_004209
	NM_011522
	NP_004200
	NP_035652
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptogyrin 3 is a protein that in humans is encoded by the SYNGR3 gene. ^[5]

Function

This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007021 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Synaptogyrin 3". Retrieved 2018-09-13.

Belizaire R, Komanduri C, Wooten K, Chen M, Thaller C, Janz R (March 2004). "Characterization of synaptogyrin 3 as a new synaptic vesicle protein". J. Comp. Neurol. 470 (3): 266–81. doi:10.1002/cne.20008. PMID 14755516. S2CID 24574182.
Peck EG, Holleran KM, Curry AM, Holter KM, Estave PM, Sens JP, et al. (August 2024). "Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits". bioRxiv. doi:10.1101/2024.07.27.605436. PMC 11361146. PMID 39211138.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127561 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007021 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Synaptogyrin 3". Retrieved 2018-09-13.

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Function

References

Further reading