TAF1B

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TAF1B
Identifiers
Aliases TAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDs MGI: 109577 HomoloGene: 31331 GeneCards: TAF1B
RNA expression pattern
PBB GE TAF1B 214690 at fs.png

PBB GE TAF1B 216941 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005680
NM_001318976
NM_001318977

NM_020614

RefSeq (protein)

NP_001305905
NP_001305906
NP_005671

NP_065639.2
NP_065639

Location (UCSC) Chr 2: 9.84 – 9.93 Mb Chr 12: 24.5 – 24.56 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.[3][4]

Function[edit]

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.[4]

Interactions[edit]

TAF1B has been shown to interact with RRN3.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.  Check date values in: |year= / |date= mismatch (help)
  4. ^ a b "Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa". 
  5. ^ Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (March 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519Freely accessible. PMID 11250903. 

Further reading[edit]