Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1gene.
This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. It is also a minor vault protein.
^Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (Jan 1998). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID9403057.
Li H, Cao Y, Berndt MC, et al. (2000). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID10597287.
Koyanagi Y, Kobayashi D, Yajima T, et al. (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Res.20 (2A): 773–8. PMID10810353.
Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Res.12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID11942411.
Zhou JH, Zhang HM, Chen Q, et al. (2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World J. Gastroenterol.9 (8): 1808–14. PMID12918126.
Li C, Wu MY, Liang YR, Wu XY (2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World J. Gastroenterol.9 (11): 2395–9. PMID14606063.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569.