TERF2IP

TERF2IP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FEX, 3K6G, 4RQI
Identifiers
Aliases	TERF2IP, DRIP5, RAP1, TERF2 interacting protein
External IDs	OMIM: 605061; MGI: 1929871; HomoloGene: 10357; GeneCards: TERF2IP; OMA:TERF2IP - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,761,872 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,747,160 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; pars compacta; ; pars reticulata; ; superior vestibular nucleus; ; pons; ; internal globus pallidus; ; lateral nuclear group of thalamus; ; Brodmann area 9; ; superior frontal gyrus;
	Top expressed in
	ventromedial nucleus; ; supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; lumbar subsegment of spinal cord; ; ventral tegmental area; ; arcuate nucleus; ; dorsal tegmental nucleus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; telomeric DNA binding; protein binding; G-rich strand telomeric DNA binding; phosphatase binding;
Cellular component	nuclear telomere cap complex; nuclear envelope; chromosome; shelterin complex; telomere; nuclear chromosome; Mre11 complex; nucleus; nucleoplasm; cytosol; nuclear body; cytoplasm;
Biological process	negative regulation of DNA recombination at telomere; telomere maintenance via telomerase; protection from non-homologous end joining at telomere; regulation of double-strand break repair via homologous recombination; transcription, DNA-templated; positive regulation of peptidyl-serine phosphorylation; protein localization to chromosome, telomeric region; positive regulation of protein acetylation; telomere maintenance via telomere lengthening; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; telomere maintenance; telomere capping; negative regulation of protein phosphorylation; regulation of transcription, DNA-templated; regulation of telomere maintenance; negative regulation of telomere maintenance; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	54386
	57321
	ENSG00000166848
	ENSMUSG00000033430
	Q9NYB0
	Q91VL8
	NM_018975
	NM_020584
	NP_061848
	NP_065609
	Wikidata
View/Edit Human	View/Edit Mouse

Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene.^[5]^[6]

Template:PBB Summary

Interactions

TERF2IP has been shown to interact with Ku80,^[7] Rad50^[7] and TERF2.^[5]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166848 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033430 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Li B, Oestreich S, de Lange T (July 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
^ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
^ ^a ^b ^c O'Connor, Matthew S; Safari Amin; Liu Dan; Qin Jun; Songyang Zhou (July 2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. 279 (27). United States: 28585–91. doi:10.1074/jbc.M312913200. ISSN 0021-9258. PMID 15100233. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Zhu, X D; Küster B; Mann M; Petrini J H; de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. 25 (3). UNITED STATES: 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading