TIMP4

TIMP4
Identifiers
Aliases	TIMP4, TIMP metallopeptidase inhibitor 4, TIMP-4
External IDs	OMIM: 601915; MGI: 109125; HomoloGene: 37748; GeneCards: TIMP4; OMA:TIMP4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	12,158,912 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,229,166 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; subcutaneous adipose tissue; ; thoracic aorta; ; left coronary artery; ; ascending aorta; ; synovial joint; ; popliteal artery; ; left ventricle; ; right lobe of thyroid gland; ; synovial membrane;
	Top expressed in
	interventricular septum; ; white adipose tissue; ; cerebellar vermis; ; motor neuron; ; substantia nigra; ; brown adipose tissue; ; myocardium of ventricle; ; soleus muscle; ; masseter muscle; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metal ion binding; protease binding; metalloendopeptidase inhibitor activity;
Cellular component	sarcomere; extracellular region; extracellular space; extracellular matrix;
Biological process	Notch signaling pathway; negative regulation of peptidase activity; response to peptide hormone; central nervous system development; response to lipopolysaccharide; ovulation cycle; negative regulation of membrane protein ectodomain proteolysis; negative regulation of catalytic activity; negative regulation of endopeptidase activity; response to hormone; response to cytokine; biological process; response to organic substance;
	Sources:Amigo / QuickGO
Orthologs
	7079
	110595
	ENSG00000157150
	ENSMUSG00000030317
	Q99727
	Q9JHB3
	NM_003256
	NM_080639; NM_001356406
	NP_003247
	NP_542370; NP_001343335
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

TIMP4 has been shown to interact with MMP2.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030317 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Greene J, Wang M, Liu YE, Raymond LA, Rosen C, Shi YE (Jan 1997). "Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4". J Biol Chem. 271 (48): 30375–30380. doi:10.1074/jbc.271.48.30375. PMID 8939999.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998). "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively". Genomics. 51 (1): 148–151. doi:10.1006/geno.1998.5362. PMID 9693046.
^ "Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4".
^ Bigg, H F; Shi Y E; Liu Y E; Steffensen B; Overall C M (Jun 1997). "Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2". J. Biol. Chem. 272 (24). UNITED STATES: 15496–15500. doi:10.1074/jbc.272.24.15496. ISSN 0021-9258. PMID 9182583. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Kai, Heidi S-T; Butler Georgina S; Morrison Charlotte J; King Angela E; Pelman Gayle R; Overall Christopher M (Dec 2002). "Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain". J. Biol. Chem. 277 (50). United States: 48696–48707. doi:10.1074/jbc.M209177200. ISSN 0021-9258. PMID 12374789. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

External links

The MEROPS online database for peptidases and their inhibitors: I35.004

Template:PBB Controls

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157150 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030317 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8939999-5] Greene J, Wang M, Liu YE, Raymond LA, Rosen C, Shi YE (Jan 1997). "Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4". J Biol Chem. 271 (48): 30375–30380. doi:10.1074/jbc.271.48.30375. PMID 8939999.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid9693046-6] Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998). "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively". Genomics. 51 (1): 148–151. doi:10.1006/geno.1998.5362. PMID 9693046.

[entrez-7] "Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4".

[pmid9182583-8] Bigg, H F; Shi Y E; Liu Y E; Steffensen B; Overall C M (Jun 1997). "Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2". J. Biol. Chem. 272 (24). UNITED STATES: 15496–15500. doi:10.1074/jbc.272.24.15496. ISSN 0021-9258. PMID 9182583. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[pmid12374789-9] Kai, Heidi S-T; Butler Georgina S; Morrison Charlotte J; King Angela E; Pelman Gayle R; Overall Christopher M (Dec 2002). "Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain". J. Biol. Chem. 277 (50). United States: 48696–48707. doi:10.1074/jbc.M209177200. ISSN 0021-9258. PMID 12374789. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

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TIMP4

Interactions

See also

References

Further reading

External links