TLE2

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TLE2
Identifiers
AliasesTLE2, ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
External IDsOMIM: 601041 MGI: 104635 HomoloGene: 20693 GeneCards: TLE2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for TLE2
Genomic location for TLE2
Band19p13.3Start2,997,639 bp[1]
End3,047,635 bp[1]
RNA expression pattern
PBB GE TLE2 204431 at fs.png

PBB GE TLE2 40837 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144761
NM_001144762
NM_001300846
NM_003260

NM_001252401
NM_019725

RefSeq (protein)

NP_001138233
NP_001138234
NP_001287775
NP_003251

NP_001239330
NP_062699

Location (UCSC)Chr 19: 3 – 3.05 MbChr 10: 81.57 – 81.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.[5][6]


Interactions[edit]

TLE2 has been shown to interact with TLE1[7] and HES1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065717 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034771 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Oct 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
  6. ^ "Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)".
  7. ^ a b Grbavec, D; Lo R; Liu Y; Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. GERMANY. 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.

Further reading[edit]