TLK2

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TLK2
Identifiers
Aliases TLK2, HsHPK, PKU-ALPHA, tousled like kinase 2
External IDs MGI: 1346023 HomoloGene: 4993 GeneCards: TLK2
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TLK2
Genomic location for TLK2
Band 17q23.2 Start 62,458,658 bp[1]
End 62,615,481 bp[1]
RNA expression pattern
PBB GE TLK2 212986 s at fs.png

PBB GE TLK2 212997 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001112707
NM_001284333
NM_001284363
NM_006852
NM_001330418

RefSeq (protein)

NP_001271262
NP_001271292
NP_001317347
NP_006843

NP_001106176
NP_001281258
NP_001281259
NP_001281260
NP_001281263

Location (UCSC) Chr 17: 62.46 – 62.62 Mb Chr 17: 105.18 – 105.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.[5][6][7]

Function[edit]

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different from other "tousled" varieties, such as flock-of-seagulls, post-coitus, or the-Sean-Bean.[supplied by OMIM][7]

Interactions[edit]

TLK2 has been shown to interact with TLK1,[6] ASF1B[8][9] and ASF1A.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146872 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020694 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T (Nov 1997). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene. 202 (1-2): 193–201. PMID 9427565. doi:10.1016/S0378-1119(97)00495-2. 
  6. ^ a b Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA (Oct 1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". The EMBO Journal. 18 (20): 5691–702. PMC 1171636Freely accessible. PMID 10523312. doi:10.1093/emboj/18.20.5691. 
  7. ^ a b "Entrez Gene: TLK2 tousled-like kinase 2". 
  8. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. PMC 1847948Freely accessible. PMID 17353931. doi:10.1038/msb4100134. 
  9. ^ a b Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. PMID 11470414. doi:10.1016/S0960-9822(01)00298-6. 

Further reading[edit]