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TM4SF1

From Wikipedia, the free encyclopedia
TM4SF1
Identifiers
AliasesTM4SF1, H-L6, L6, M3S1, TAAL6, transmembrane 4 L six family member 1
External IDsOMIM: 191155; MGI: 104678; HomoloGene: 7409; GeneCards: TM4SF1; OMA:TM4SF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014220

NM_008536
NM_001355130

RefSeq (protein)

NP_055035

NP_032562
NP_001342059

Location (UCSC)Chr 3: 149.37 – 149.38 MbChr 3: 57.19 – 57.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.[5][6]

Function

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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.[6]

Marker gene for alveolar epithelial progenitors

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TM4SF1 has been identified as a marker of Wnt-responsive alveolar epithelial progenitor cells, and a marker of alveolar repair in injured regions of the lungs.[7] It has also been found hypomethylated and upregulated in asthma, with potential prognostic value (AUROC: 0.769).[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169908Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027800Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. Bibcode:1992PNAS...89.3503M. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.
  6. ^ a b "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".
  7. ^ Zacharias, William J.; Frank, David B.; Zepp, Jarod A.; Morley, Michael P.; Alkhaleel, Farrah A.; Kong, Jun; Zhou, Su; Cantu, Edward; Morrisey, Edward E. (2018-03-08). "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor". Nature. 555 (7695): 251–255. Bibcode:2018Natur.555..251Z. doi:10.1038/nature25786. ISSN 1476-4687. PMC 6020060. PMID 29489752.
  8. ^ Wang, Zongling; Wang, Lizhi; Dai, Lina; Wang, Yanan; Li, Erhong; An, Shuyuan; Wang, Fengliang; Liu, Dan; Pan, Wen (2022-12-22). "Identification of candidate aberrant differentially methylated/expressed genes in asthma". Allergy, Asthma, and Clinical Immunology. 18 (1): 108. doi:10.1186/s13223-022-00744-5. ISSN 1710-1484. PMC 9784293. PMID 36550577.

Further reading

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