TM4SF5

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TM4SF5
Identifiers
Aliases TM4SF5
External IDs MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5
RNA expression pattern
PBB GE TM4SF5 206242 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003963

NM_029360

RefSeq (protein)

NP_003954

n/a

Location (UCSC) Chr 17: 4.77 – 4.78 Mb Chr 11: 70.51 – 70.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[3][4]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene. 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038. 
  4. ^ a b "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5". 

Further reading[edit]