TMED2

TMED2
Identifiers
Aliases	TMED2, P24A, RNP24, p24, p24b1, p24beta1, transmembrane p24 trafficking protein 2
External IDs	MGI: 3704329; HomoloGene: 55991; GeneCards: TMED2; OMA:TMED2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	123,598,582 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; corpus epididymis; ; pylorus; ; pericardium; ; trachea; ; caput epididymis; ; cardia; ; human penis; ; superior surface of tongue; ; Epithelium of choroid plexus;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	transport vesicle; integral component of membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; Golgi cisterna membrane; zymogen granule membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; COPI-coated vesicle; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment; COPI-coated vesicle membrane; COPII-coated ER to Golgi transport vesicle;
Biological process	vesicle cargo loading; neural tube closure; maternal placenta development; embryonic placenta development; COPII vesicle coating; endoplasmic reticulum to Golgi vesicle-mediated transport; heart looping; positive regulation of gene expression; somitogenesis; Golgi organization; post-anal tail morphogenesis; embryonic morphogenesis; multicellular organism growth; in utero embryonic development; protein transport; negative regulation of GTPase activity; COPI coating of Golgi vesicle; labyrinthine layer blood vessel development; vesicle-mediated transport; somite rostral/caudal axis specification; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10959
	100862175
	ENSG00000086598
	n/a
	Q15363
	Q9R0Q3
	NM_006815; NM_001321445
	XM_003945446
	NP_001308374; NP_006806
	NP_062744; NP_001390182; NP_001390186
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.^[4]^[5] Template:PBB Summary

Interactions

TMED2 has been shown to interact with GORASP1^[6] and GORASP2.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086598 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (September 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".
^ ^a ^b Barr, F A; Preisinger C; Kopajtich R; Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6). United States: 885–91. doi:10.1083/jcb.200108102. ISSN 0021-9525. PMC 2150891. PMID 11739402. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading