TNKS1BP1

TNKS1BP1
Identifiers
Aliases	TNKS1BP1, TAB182, tankyrase 1 binding protein 1
External IDs	OMIM: 607104; MGI: 2446193; HomoloGene: 14117; GeneCards: TNKS1BP1; OMA:TNKS1BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	57,324,952 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,903,392 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; skin of abdomen; ; skin of leg; ; ectocervix; ; canal of the cervix; ; body of stomach; ; minor salivary glands; ; right coronary artery; ; right lobe of liver; ; upper lobe of left lung;
	Top expressed in
	lip; ; ankle joint; ; dentate gyrus of hippocampal formation granule cell; ; esophagus; ; gastrula; ; corneal stroma; ; stomach; ; primary visual cortex; ; lacrimal gland; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; enzyme binding; ankyrin repeat binding; cadherin binding; protein-containing complex binding;
Cellular component	chromosome; CCR4-NOT complex; cytosol; cytoskeleton; nucleus; cytoplasm;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; telomere maintenance via telomerase; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein autophosphorylation; positive regulation of peptidyl-serine phosphorylation; cellular response to ionizing radiation;
	Sources:Amigo / QuickGO
Orthologs
	85456
	228140
	ENSG00000149115
	ENSMUSG00000033955
	Q9C0C2
	P58871
	NM_033396
	NM_001081260
	NP_203754
	NP_001074729
	Wikidata
View/Edit Human	View/Edit Mouse

182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene.^[5]^[6]

Interactions

TNKS1BP1 has been shown to interact with TNKS.^[5]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149115 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033955 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Seimiya H, Smith S (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J Biol Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
^ "Entrez Gene: TNKS1BP1 tankyrase 1 binding protein 1, 182kDa".
^ Sbodio JI, Chi NW (Aug 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T (2005). "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics". Cancer Cell. 7 (1): 25–37. doi:10.1016/j.ccr.2004.11.021. PMID 15652747.
Chang P, Coughlin M, Mitchison TJ (2006). "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function". Nat. Cell Biol. 7 (11): 1133–9. doi:10.1038/ncb1322. PMID 16244666. S2CID 12416419.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gelmini S, Quattrone S, Malentacchi F, Villari D, Travaglini F, Giannarini G, Della Melina A, Pazzagli M, Nicita G, Selli C, Orlando C (2007). "Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience". Clin. Chem. Lab. Med. 45 (7): 862–6. doi:10.1515/CCLM.2007.133. PMID 17617028. S2CID 22726749.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149115 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033955 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11854288-5] Seimiya H, Smith S (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J Biol Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.

[entrez-6] "Entrez Gene: TNKS1BP1 tankyrase 1 binding protein 1, 182kDa".

[pmid12080061-7] Sbodio JI, Chi NW (Aug 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.

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Interactions

References

Further reading