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Aliases TNKS1BP1, TAB182, tankyrase 1 binding protein 1
External IDs MGI: 2446193 HomoloGene: 14117 GeneCards: TNKS1BP1
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 57.3 – 57.32 Mb Chr 2: 85.05 – 85.07 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene.[3][4]


TNKS1BP1 has been shown to interact with TNKS.[3][5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Seimiya H, Smith S (Apr 2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J Biol Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288. 
  4. ^ "Entrez Gene: TNKS1BP1 tankyrase 1 binding protein 1, 182kDa". 
  5. ^ Sbodio JI, Chi NW (Aug 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061. 

Further reading[edit]

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
  • Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  • Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061. 
  • Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446Freely accessible. PMID 15302935. 
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 
  • Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T (2005). "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.". Cancer Cell. 7 (1): 25–37. doi:10.1016/j.ccr.2004.11.021. PMID 15652747. 
  • Chang P, Coughlin M, Mitchison TJ (2006). "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function.". Nat. Cell Biol. 7 (11): 1133–9. doi:10.1038/ncb1322. PMID 16244666. 
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Gelmini S, Quattrone S, Malentacchi F, Villari D, Travaglini F, Giannarini G, Della Melina A, Pazzagli M, Nicita G, Selli C, Orlando C (2007). "Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.". Clin. Chem. Lab. Med. 45 (7): 862–6. doi:10.1515/CCLM.2007.133. PMID 17617028.