TNRC6A

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TNRC6A
Identifiers
Aliases TNRC6A, CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A
External IDs MGI: 2385292 HomoloGene: 41399 GeneCards: TNRC6A
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014494
NM_001330520

NM_144925

RefSeq (protein)

NP_001317449
NP_055309

NP_659174.3
NP_659174

Location (UCSC) Chr 16: 24.61 – 24.83 Mb Chr 7: 123.12 – 123.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.[3][4]

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. 
  4. ^ a b "Entrez Gene: TNRC6A trinucleotide repeat containing 6A". 

Further reading[edit]