TOB2

TOB2
Identifiers
Aliases	TOB2, TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDs	OMIM: 607396; MGI: 1888525; HomoloGene: 9447; GeneCards: TOB2; OMA:TOB2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,446,801 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,742,997 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; paraflocculus of cerebellum; ; gastric mucosa; ; mucosa of paranasal sinus; ; muscle of thigh; ; popliteal artery; ; tibial arteries; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	ascending aorta; ; aortic valve; ; retinal pigment epithelium; ; ciliary body; ; neural layer of retina; ; brown adipose tissue; ; epithelium of lens; ; medial head of gastrocnemius muscle; ; primary oocyte; ; masseter muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; vitamin D receptor binding; transcription corepressor activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	positive regulation of ossification; female gamete generation; negative regulation of osteoclast differentiation; regulation of gene expression; negative regulation of cell population proliferation; signaling; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	10766
	57259
	ENSG00000183864
	ENSMUSG00000048546
	Q14106
	Q9JM55
	NM_016272
	NM_020507
	NP_057356
	NP_065253
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Tob2 is a protein that in humans is encoded by the TOB2 gene.^[5]^[6]^[7]

Interactions

TOB2 has been shown to interact with CNOT7.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183864 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048546 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Jan 2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: TOB2 transducer of ERBB2, 2".