TOP2A

TOP2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZXM, 1ZXN, 4FM9, 4R1F
Identifiers
Aliases	TOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha
External IDs	OMIM: 126430; MGI: 98790; HomoloGene: 830; GeneCards: TOP2A; OMA:TOP2A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,417,896 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,915,015 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; secondary oocyte; ; right testis; ; left testis; ; bone marrow; ; trabecular bone; ; gonad; ; bone marrow cells; ; testicle;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; primitive streak; ; mandibular prominence; ; epiblast; ; tibiofemoral joint; ; somite;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; protein homodimerization activity; histone deacetylase binding; chromatin binding; isomerase activity; metal ion binding; DNA topoisomerase activity; protein C-terminus binding; ubiquitin binding; protein binding; protein heterodimerization activity; enzyme binding; ATP binding; protein kinase C binding; magnesium ion binding; DNA binding, bending; RNA binding; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;
Cellular component	cytoplasm; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; nucleoplasm; nuclear chromosome; nucleolus; centriole; condensed chromosome; nucleus; viral integration complex; protein-containing complex; ribonucleoprotein complex;
Biological process	resolution of meiotic recombination intermediates; apoptotic chromosome condensation; embryonic cleavage; rhythmic process; chromosome segregation; DNA metabolic process; protein sumoylation; cellular response to DNA damage stimulus; DNA ligation; chromosome condensation; regulation of circadian rhythm; hematopoietic progenitor cell differentiation; positive regulation of apoptotic process; mitotic DNA integrity checkpoint signaling; positive regulation of viral genome replication; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; sister chromatid segregation; positive regulation of transcription by RNA polymerase II; DNA topological change; negative regulation of DNA duplex unwinding; female meiotic nuclear division;
	Sources:Amigo / QuickGO
Orthologs
	7153
	21973
	ENSG00000131747
	ENSMUSG00000020914
	P11388
	Q01320
	NM_001067
	NM_011623
	NP_001058
	NP_035753
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.

Template:PBB Summary

Interactions

TOP2A has been shown to interact with HDAC1,^[5]^[6] CDC5L,^[7] Small ubiquitin-related modifier 1^[8] and P53.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131747 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020914 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsai, S C; Valkov N; Yang W M; Gump J; Sullivan D; Seto E (November 2000). "Histone deacetylase interacts directly with DNA topoisomerase II". Nat. Genet. 26 (3). UNITED STATES: 349–53. doi:10.1038/81671. ISSN 1061-4036. PMID 11062478. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Johnson, C A; Padget K; Austin C A; Turner B M (February 2001). "Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis". J. Biol. Chem. 276 (7). United States: 4539–42. doi:10.1074/jbc.C000824200. ISSN 0021-9258. PMID 11136718. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23). ENGLAND: 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Mao, Y; Desai S D; Liu L F (August 2000). "SUMO-1 conjugation to human DNA topoisomerase II isozymes". J. Biol. Chem. 275 (34). UNITED STATES: 26066–73. doi:10.1074/jbc.M001831200. ISSN 0021-9258. PMID 10862613. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Cowell, I G; Okorokov A L; Cutts S A; Padget K; Bell M; Milner J; Austin C A (February 2000). "Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53". Exp. Cell Res. 255 (1). UNITED STATES: 86–94. doi:10.1006/excr.1999.4772. ISSN 0014-4827. PMID 10666337. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading