TPX2

TPX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OL5, 3E5A, 3HA6, 4C3P
Identifiers
Aliases	TPX2, C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, microtubule nucleation factor, TPX2 microtubule nucleation factor
External IDs	OMIM: 605917; MGI: 1919369; HomoloGene: 8107; GeneCards: TPX2; OMA:TPX2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	31,801,805 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,737,241 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; oocyte; ; gonad; ; secondary oocyte; ; bone marrow; ; testicle; ; trabecular bone; ; right testis; ; left testis;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; zygote; ; fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; primitive streak; ; epiblast; ; endothelial cell of lymphatic vessel; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding; importin-alpha family protein binding; ATP binding; protein binding; protein kinase binding;
Cellular component	cytoplasm; nucleus; spindle pole; microtubule; microtubule cytoskeleton; axon hillock; cytoskeleton; spindle; cytosol; nucleoplasm; mitotic spindle; microtubule organizing center; intercellular bridge;
Biological process	regulation of mitotic spindle organization; cell cycle; cell division; apoptotic process; mitotic spindle assembly; cell population proliferation; activation of protein kinase activity; regulation of signal transduction by p53 class mediator; mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	22974
	72119
	ENSG00000088325
	ENSMUSG00000027469
	Q9ULW0
	A2APB8
	NM_012112
	NM_001141975; NM_001141976; NM_001141977; NM_001141978; NM_028109
	NP_036244
	NP_001135447; NP_001135448; NP_001135449; NP_001135450; NP_082385
	Wikidata
View/Edit Human	View/Edit Mouse

Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. ^[5]^[6]^[7]

Template:PBB Summary

Interactions

TPX2 has been shown to interact with Aurora A kinase ^[8], KIF15, and Ran.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088325 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027469 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Heidebrecht HJ, Buck F, Steinmann J, Sprenger R, Wacker HH, Parwaresch R (Jul 1997). "p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M". Blood. 90 (1): 226–33. PMID 9207457.
^ Zhang Y, Heidebrecht H, Rott A, Schlegelberger B, Parwaresch R (Jul 1999). "Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization". Cytogenet Cell Genet. 84 (3–4): 182–3. doi:10.1159/000015251. PMID 10393424.
^ "Entrez Gene: TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis)".
^ Kufer, Thomas A; Silljé Herman H W; Körner Roman; Gruss Oliver J; Meraldi Patrick; Nigg Erich A (Aug 2002). "Human TPX2 is required for targeting Aurora-A kinase to the spindle". J. Cell Biol. 158 (4). United States: 617–23. doi:10.1083/jcb.200204155. ISSN 0021-9525. PMC 2174010. PMID 12177045. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading