TRAF3IP2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
TRAF3IP2
Identifiers
Aliases TRAF3IP2, ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13, TRAF3 interacting protein 2
External IDs MGI: 2143599 HomoloGene: 15885 GeneCards: TRAF3IP2
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TRAF3IP2
Genomic location for TRAF3IP2
Band 6q21 Start 111,556,454 bp[1]
End 111,606,278 bp[1]
RNA expression pattern
PBB GE TRAF3IP2 215411 s at fs.png

PBB GE TRAF3IP2 202987 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164281
NM_001164282
NM_001164283
NM_147200
NM_147686

NM_134000

RefSeq (protein)

NP_001157753
NP_001157755
NP_671733
NP_679211

NP_598761

Location (UCSC) Chr 6: 111.56 – 111.61 Mb Chr 10: 39.61 – 39.66 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.[5][6][7]

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.[7]

Interactions[edit]

TRAF3IP2 has been shown to interact with IKBKG.[5][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000056972 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019842 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U (Oct 2000). "CIKS, a connection to Ikappa B kinase and stress-activated protein kinase". Proc Natl Acad Sci U S A. 97 (19): 10494–9. doi:10.1073/pnas.190245697. PMC 27052Freely accessible. PMID 10962033. 
  6. ^ a b Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR (Oct 2000). "Act1, an NF-kappa B-activating protein". Proc Natl Acad Sci U S A. 97 (19): 10489–93. doi:10.1073/pnas.160265197. PMC 27051Freely accessible. PMID 10962024. 
  7. ^ a b "Entrez Gene: TRAF3IP2 TRAF3 interacting protein 2". 

Further reading[edit]