This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
Morelli C, Magnanini C, Mungall AJ, et al. (2000). "Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia.". Gene. 252 (1–2): 217–25. doi:10.1016/S0378-1119(00)00231-6. PMID10903453.
Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID12133833.
Xia YF, Li YD, Li X, Geng JG (2002). "Identification of alternatively spliced Act1 and implications for its roles in oncogenesis". Biochem. Biophys. Res. Commun. 296 (2): 406–12. doi:10.1016/S0006-291X(02)00887-2. PMID12163033.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID12761501.