TRERF1

TRERF1
Identifiers
Aliases	TRERF1, BCAR2, HSA277276, RAPA, TREP132, TReP-132, dJ139D8.5, transcriptional regulating factor 1
External IDs	OMIM: 610322; MGI: 2442086; HomoloGene: 14129; GeneCards: TRERF1; OMA:TRERF1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	42,452,051 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	47,672,883 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; cartilage tissue; ; Brodmann area 23; ; parietal pleura; ; middle temporal gyrus; ; blood; ; pancreatic ductal cell; ; buccal mucosa cell; ; primary visual cortex; ; gums;
	Top expressed in
	Rostral migratory stream; ; pyramidal layer of hippocampus; ; molecular layer of dentate gyrus; ; nucleus accumbens; ; olfactory tubercle; ; dorsal striatum; ; temporal lobe; ; medullary collecting duct; ; substantia nigra; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; transcription coregulator activity; DNA binding; DNA binding, bending; nuclear receptor coactivator activity; transcription factor binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; histone deacetylase complex; transcription regulator complex; nucleoplasm; nucleolus; cytosol;
Biological process	multicellular organism development; cholesterol catabolic process; regulation of transcription, DNA-templated; homeostatic process; steroid biosynthetic process; positive regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of hormone biosynthetic process; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	55809
	224829
	ENSG00000124496
	ENSMUSG00000064043
	Q96PN7
	Q8BXJ2
NM_001297573; NM_018415; NM_033501; NM_033502; NM_001391983;
	NM_001391984; NM_001395490
	NM_001097623; NM_172622
	NP_001284502; NP_277037
	NP_001091092; NP_766210
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.^[5]^[6]

Template:PBB Summary

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,^[7] EP300^[5] and CREB-binding protein.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064043 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Gizard F, Lavallee B, DeWitte F, Hum DW (Sep 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". J Biol Chem. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: TRERF1 transcriptional regulating factor 1".
^ Gizard, Florence; Lavallee Bernard; DeWitte Frederique; Teissier Elisabeth; Staels Bart; Hum Dean W (Oct 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". J. Biol. Chem. 277 (42). United States: 39144–55. doi:10.1074/jbc.M205786200. ISSN 0021-9258. PMID 12101186. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading