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Aliases TRIM27, RFP, RNF76, tripartite motif containing 27
External IDs MGI: 97904 HomoloGene: 111010 GeneCards: TRIM27
RNA expression pattern
PBB GE TRIM27 210541 s at fs.png

PBB GE TRIM27 212116 at fs.png

PBB GE TRIM27 212118 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 28.9 – 28.92 Mb Chr 13: 21.18 – 21.19 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.[3][4]

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.[4]


TRIM27 has been shown to interact with PRAM1[5] and EIF3S6.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Vernet C, Boretto J, Mattei MG, Takahashi M, Jack LJ, Mather IH, Rouquier S, Pontarotti P (Mar 1994). "Evolutionary study of multigenic families mapping close to the human MHC class I region". J Mol Evol. 37 (6): 600–12. doi:10.1007/bf00182746. PMID 8114113. 
  4. ^ a b "Entrez Gene: TRIM27 tripartite motif-containing 27". 
  5. ^ Cao, T; Duprez E; Borden K L; Freemont P S; Etkin L D (May 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell. Sci. ENGLAND. 111 (10): 1319–29. ISSN 0021-9533. PMID 9570750. 
  6. ^ Morris-Desbois, C; Bochard V; Reynaud C; Jalinot P (Oct 1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies". J. Cell. Sci. ENGLAND. 112 (19): 3331–42. ISSN 0021-9533. PMID 10504338. 

Further reading[edit]