TRIM3

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TRIM3
Identifiers
Aliases TRIM3, BERP, HAC1, RNF22, RNF97, tripartite motif containing 3
External IDs MGI: 1860040 HomoloGene: 21290 GeneCards: TRIM3
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TRIM3
Genomic location for TRIM3
Band 11p15.4 Start 6,448,613 bp[1]
End 6,474,459 bp[1]
RNA expression pattern
PBB GE TRIM3 204910 s at fs.png

PBB GE TRIM3 204911 s at fs.png

PBB GE TRIM3 213884 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001248006
NM_001248007
NM_006458
NM_033278

NM_001285870
NM_001285871
NM_001285873
NM_018880

RefSeq (protein)

NP_001234935
NP_001234936
NP_006449
NP_150594

NP_001272799
NP_001272800
NP_001272802
NP_061368

Location (UCSC) Chr 11: 6.45 – 6.47 Mb Chr 11: 105.6 – 105.63 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.[5][6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.[6]

Interactions[edit]

TRIM3 has been shown to interact with Actinin alpha 4.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110171 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036989 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ El-Husseini AE, Vincent SR (August 1999). "Cloning and characterization of a novel RING finger protein that interacts with class V myosins". J Biol Chem. 274 (28): 19771–7. doi:10.1074/jbc.274.28.19771. PMID 10391919. 
  6. ^ a b "Entrez Gene: TRIM3 tripartite motif-containing 3". 
  7. ^ El-Husseini, A E; Kwasnicka D; Yamada T; Hirohashi S; Vincent S R (January 2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. UNITED STATES. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. ISSN 0006-291X. PMID 10673389. 

Further reading[edit]