TSEN34

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TSEN34
Identifiers
Aliases TSEN34, LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDs MGI: 1913328 HomoloGene: 44182 GeneCards: TSEN34
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077446
NM_001282332
NM_001282333
NM_024075

NM_001164204
NM_001164205
NM_024168

RefSeq (protein)

NP_001070914
NP_001269261
NP_001269262
NP_076980

Location (UCSC) Chr 19: 54.19 – 54.19 Mb Chr 7: 3.69 – 3.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.[3][4][5]

tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][5]

Interactions[edit]

TSEN34 has been shown to interact with TSEN2.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8-9): 703–13. doi:10.1007/s002510000187. PMID 10941842. 
  4. ^ a b Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. 
  5. ^ a b "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)". 

Further reading[edit]


External links[edit]