TUB (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein TUB PDB 1c8z.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TUB, rd5, RDOB, tubby bipartite transcription factor
External IDs MGI: 2651573 HomoloGene: 31147 GeneCards: TUB
RNA expression pattern
PBB GE TUB 210737 at fs.png

PBB GE TUB 208431 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 8.02 – 8.11 Mb Chr 7: 108.95 – 109.03 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Tubby protein homolog is a protein that in humans is encoded by the TUB gene.[3][4]

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.[4]


TUB (gene) has been shown to interact with PLCG1.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ (Jun 1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell. 85 (2): 281–90. doi:10.1016/S0092-8674(00)81104-6. PMID 8612280. 
  4. ^ a b "Entrez Gene: TUB tubby homolog (mouse)". 
  5. ^ Kapeller, R; Moriarty A; Strauss A; Stubdal H; Theriault K; Siebert E; Chickering T; Morgenstern J P; Tartaglia L A; Lillie J (Aug 1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. UNITED STATES. 274 (35): 24980–6. doi:10.1074/jbc.274.35.24980. ISSN 0021-9258. PMID 10455176. 

Further reading[edit]