TUB (gene)

TUB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S31
Identifiers
Aliases	TUB, rd5, RDOB, tubby bipartite transcription factor, TUB bipartite transcription factor
External IDs	OMIM: 601197; MGI: 2651573; HomoloGene: 31147; GeneCards: TUB; OMA:TUB - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	8,106,243 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	108,633,667 bp
RNA expression pattern
	Top expressed in
	pars reticulata; ; Pars compacta; ; middle temporal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; superior frontal gyrus; ; superior vestibular nucleus; ; pons; ; ventral tegmental area; ; pituitary gland;
	Top expressed in
	neural layer of retina; ; dorsomedial hypothalamic nucleus; ; arcuate nucleus; ; subiculum; ; ventromedial nucleus; ; anterior amygdaloid area; ; paraventricular nucleus of hypothalamus; ; dentate gyrus of hippocampal formation granule cell; ; habenula; ; lateral hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol binding; protein-containing complex binding; G protein-coupled receptor binding; intraciliary transport particle A binding;
Cellular component	cytoplasm; extracellular region; cytosol; plasma membrane; cilium; membrane; nucleus;
Biological process	phagocytosis, recognition; receptor localization to non-motile cilium; response to hormone; positive regulation of phagocytosis; photoreceptor cell maintenance; hearing; retina development in camera-type eye; protein localization to photoreceptor outer segment; response to stimulus; phagocytosis; protein localization to cilium; regulation of G protein-coupled receptor signaling pathway; intraciliary transport;
	Sources:Amigo / QuickGO
Orthologs
	7275
	22141
	ENSG00000166402
	ENSMUSG00000031028
	P50607
	P50586
	NM_003320; NM_177972
	NM_021885
	NP_003311; NP_813977
	NP_068685
	Wikidata
View/Edit Human	View/Edit Mouse

Tubby protein homolog is a protein that in humans is encoded by the TUB gene.^[5]^[6]

Template:PBB Summary

Interactions

TUB (gene) has been shown to interact with PLCG1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031028 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ (Jun 1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell. 85 (2): 281–90. doi:10.1016/S0092-8674(00)81104-6. PMID 8612280.
^ "Entrez Gene: TUB tubby homolog (mouse)".
^ Kapeller, R; Moriarty A; Strauss A; Stubdal H; Theriault K; Siebert E; Chickering T; Morgenstern J P; Tartaglia L A; Lillie J (Aug 1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. 274 (35). UNITED STATES: 24980–6. doi:10.1074/jbc.274.35.24980. ISSN 0021-9258. PMID 10455176. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading